bromonordiazepam

Description

General information Bromonordiazepam

Bromazepam is a benzodiazepine. It is mainly an anti-anxiety drug with similar after-effects to diazepam (valium). Bromazepam is not only used to treat tension or rage, but can also be used as premedication prior to a minor medical procedure. Bromazepam regularly comes in portions of 3 mg and 6 mg tablets.

It was licensed by Roche in 1961 and approved for clinical use in 1974.

After overnight administration of bromazepam, a very sharp reduction in gastric acid secretion occurs during rest, followed by an exceptionally critical rebound of gastric acid test substance the next day.

Chemical composition of bromonordiazepam

Its conventional name is 7-bromo-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepine-2-on. The molecular equation of bromazepam is C15H11BrN2O. Bromazepam is a scientific reference standard sorted as a metabolite of benzodiazepine.1 Desalkylgidazepam is a metabolite of gidazepam. This exploration compound is planned for forensic and research applications.

Pharmacology of bromonordiazepam

Bromazepam is a "classic" benzodiazepine; other old-style benzodiazepines include: diazepam, clonazepam, oxazepam, lorazepam, nitrazepam, flurazepam and clorazepate. The molecular structure is made of a diazepine associated with a benzene ring and a pyridine ring, where the benzene ring has a lone nitrogen particle that replaces one of the carbon molecules in the ring structure. It is a 1,4-benzodiazepine, implying that the nitrogen atoms on the seven-sided diazepine ring are in the 1 and 4 positions.

Bromazepam binds to the GABA receptor GABAA, causing a conformational change and extending the inhibitory effects of GABA. It acts as a positive modulator and develops receptor response when initiated by GABA itself or an agonist (such as liquor). Instead of barbital, BZDs are not GABA receptor activators and rely on extending the biological activity of the synapse. Bromazepam is a semiactive benzodiazepine, is moderately lipophilic unlike other substances in its group and is utilised via oxidative pathways in the liver. It has no stimulant or antipsychotic properties.

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